Clinically, cutaneous mycobacterial infections present with widely different clinical presentations, including cellulitis, nonhealing ulcers, subacute or chronic nodular lesions, abscesses, superficial lymphadenitis, verrucous lesions, and other types of findings. Leprosy occupies a prominent position among infectious diseases due to its high frequency of disability and associated stigma (75–78). The most frequently identified mycobacterial pathogens involving the skin and soft tissues include Mycobacterium leprae Mycobacterium ulcerans and M. tuberculosis. Created 2008. M. kansasii infection manifests predominantly as pulmonary disease. Free-living amoebas, including Acanthamoeba or Vermamoeba, may act as reservoirs of M. leprae and NTM (38–41). This form of cutaneous tuberculosis is also associated with infection caused by Mycobacterium bovis or bacillus Calmette-Guérin. In 1947, Mycobacterium ulcerans was identified as the cause of Buruli ulcer (BU) (2, 3, 31, 32, 109–111). He is part of the Executive Board of the Latin American Society for Travel Medicine (SLAMVI). Along with Mycobacterium fortuitum and Mycobacterium chelonae, members of the M. abscessus complex (M. abscessus, Mycobacterium massiliense, and Mycobacterium bolletii) are the major NTM associated with cutaneous involvement (Fig. Foulon M, Robbe-Saule M, Manry J, Esnault L, Boucaud Y, Alcaïs A, Malloci M, Fanton d'Andon M, Beauvais T, Labarriere N, Jeannin P, Abel L, Saint-André JP, Croué A, Delneste Y, Boneca IG, Marsollier L, Marion E. PLoS Pathog. Mycobacterium chelonae is a nonchromogenic and rapidly growing mycobacteria (Figure 17) that is widely recoverable from man-made environment such as tap water or from fresh and seawater.The most common clinical manifestations are skin, soft tissue, and bone infections … The following discussion will focus on non tuberculous mycobacteriu… 4) (72, 74, 78). The management of leprosy requires the use of MDT in combination with steroids or other anti-inflammatory drugs among those with leprosy reactions (72, 74, 78). Skin and soft tissue (typically following surgery, trauma, injection of medications or other substances) Device associated infections (e.g., central line associated bloodstream infection, exit site infections, pacemaker pocket site infections… He is President of the Travel Medicine Committee of the Pan American Infectious Diseases Association (API), as well Secretary of the Colombian Infectious Diseases Association (ACIN). There is also some evidence suggesting that M. lepromatosis may be associated with severe leprosy reactions, but this association requires further confirmation (103, 107). 8). The pathogenesis of cutaneous mycobacterial infections is the result of hematogenous dissemination, local or regional spread from a deep-seated infection, or direct inoculation into the skin and soft tissues (24). Scrofuloderma is a form of TB that is caused by M. tuberculosis or M. bovis and commonly affects children, adolescents, and older adults (47, 69). Enter multiple addresses on separate lines or separate them with commas. He is Professor of Infectology and Tropical Medicine (University of Sucre, Colombia), Professor of the Graduate Promotion and Prevention of the University of Sucre (Colombia), member of the Research Committee of the University Hospital of Sinclejo (Colombia), Colciencias peer reviewer, coordinator of the Tropical Medicine and Zoonoses Committee of the Colombian Association of Infectology (2017 to 2019), and member of the editing and arbitration committees of multiple international journals. From an ecological standpoint, BU is a mycobacterial disease identified in rural areas with wetlands, such as ponds, swamps, marshes, impoundments, backwaters, slow-moving rivers, and flooding areas (31, 32). 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